Research Guides: Evidence-Based Medicine: Clinical Research

Understand Clinical Research

Understanding Clinical Research by Robert A. Harrington; Renato D. Lopes
Publication Date: 2013
Guide to understanding and applying clinical research results.
"I Don't Know What to Believe..." Making Sense of Science Stories by Sense About Science
Publication Date: 2005; updated 2017
Explains how scientists present and judge research and the questions you can ask when presented with scientific and medical information.
What is critical appraisal? by Amanda Burls
Publication Date: 2014
Defines critical appraisal and explains reliability, question types, study designs, randomised controlled studies, validity, and ratios.
Basic & Clinical Biostatistics, 4th ed. by Beth Dawson; Robert G. Trapp
Publication Date: 2019

Trip: Turning Research Into Practice
Clinical search engine designed to find and use high-quality research evidence to support their practice and/or care. Includes a PICO search option.

CenterWatch
Find clinical trials, search for drug information, and review definitions of commonly-used clinical research terms.
ClinicalTrials.gov
Registry and results database of federally and privately supported clinical trials conducted in the United States and around the world.
European Union Clinical Trials Register
Search for protocol and results information on: interventional clinical trials that are conducted in the European Union (EU) and the European Economic Area (EEA); and clinical trials conducted outside the EU / EEA that are linked to European paediatric-medicine development.
ISRCTN Registry
Primary clinical trial registry that accepts all clinical research studies (whether proposed, ongoing or completed), providing content validation and curation and the unique identification number necessary for publication.
Search Healthy People Evidence-Based Resources
Search over 350 evidence-based resources.

CINAHL® Complete This link opens in a new window
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Filter by Clinical Queries, Research Article, Evidence-Based Practice, or Randomized Controlled Trials, or by Publication Type (e.g., case study, clinical trial, etc.)
ProQuest Health & Medicine This link opens in a new window
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Search 13 ProQuest health and medicine databases at once.
PubMed This link opens in a new window
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Filter by Article type (e.g., clinical trial, randomized controlled trial, etc.).

PubMed Clinical Queries
Results of searches on this page are limited to specific clinical study categories and scope, as well as systematic reviews.

MEDLINE Search Strategies by Question Type
This document breaks down the four types of clinical foreground questions and provides you with the optimal study designs, appropriate MeSH terms based on the question type, as well as appropriate subheadings to utilize with your various search terms.